CXCR5+ T helper cells mediate protective immunity against tuberculosis

CXCR5⁺ T helper cells mediate protective immunity against tuberculosis.

One third of the world's population is infected with Mycobacterium tuberculosis (Mtb). Although most infected people remain asymptomatic, they have a 10% lifetime risk of developing active tuberculosis (TB). Thus, the current challenge is to identify immune parameters that distinguish individuals with latent TB from those with active TB. Using human and experimental models of Mtb infection, we ...

Mediate Protective Tuberculosis Immunity

Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses.

Two zoonotic coronaviruses (CoVs)-SARS-CoV and MERS-CoV-have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4(+) T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavirus vaccines. Airway memory CD4(+) T cells differed phenotypically and functionally from lung-deri...

Subspecialization of CXCR5 T Cells: B Helper Activity Is Focused in a Germinal Center–localized Subset of CXCR5 T Cells

The T helper (Th) cell pool is composed of specialized cells with heterogeneous effector functions. Apart from Th1 and 2 cells, CXCR5 T cells have been suggested to be another type of effector T cell specialized for B cell help. We show here that CXCR5 T cells are heterogeneous, and we identify subsets of CXCR5 CD4 T cells that differ in function and microenvironmental localization in secondary...

Eosinophils Mediate Protective Immunity